ABSTRACT
ThisstudywasaimedtoobservetheinhibitoryeffectsofQi-Zhu (QZ)granulesonearlyproteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. A total of 44 rats were randomly divided into the blank group, model group, Huang-Kui capsule group, QZ granules group. The rat model of diabetic nephropathy with syndrome of qi-yin deficiency and phlegm blocking collaterals was induced by the combination of unilateral renal artery ligation, diet of high-calorie and high cholesterol, and intraperitoneal injection of low-dose streptozotocin. The medication was given for 8 weeks. The concentrations of protein and creatinine in urine were observed on the 4th week. The blood glucose, blood lipids, liver function and renal pathological changes were observed at the end of the experiment. The results showed that compared with the model group, QZ granules can obvious suppress early proteinuria in diabetic nephropathy, promote creatinine excretion, regulate blood lipid metabolism, protect liver function and improve renal pathological changes. It was concluded that QZ granules had independent inhibition effect on early proteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. The effect was independent of lowing blood glucose. It represented the corresponding relation between the syndrome and efficacy in Chinese herb compounds.
ABSTRACT
<p><b>OBJECTIVE</b>To provide a new approach for studying the compatibility principle of traditional Chinese medicine formula (TCMF) by constructing compatibility network of phamarcologic action of TCMF according to the network theory.</p><p><b>METHOD</b>With Chinese herb as node and compatibility relationship of herb-herb as edge according to network theory, compatibility network of phamarcologic action of TCMF was constructed after the compatibility relationship of herb-herb was analysed by two-way analysis of variance (ANOVA)through phamarcology experiment. Then compatibility principle of TCMF was analysed with network efficiency (NE) and NE related parameters.</p><p><b>RESULT</b>The network approach was applied for studying compatibility principle of Jiawei Shengmai San on it's antimyocardial ischemia reperfusion injury action. The results indicated that rhizoma corydalis was the main herb in Jiawei Shengmai San, and in turn was radix ophiopogonois, radix salvia miltiorrhiza, radix ginseng and fructus schizandrae, radix ginseng and radix salvia was clustered first, and in turn was radix, Formule composed of ophiopogonois and fructus schizandrae. Formule composed of radix ginseng and radix salvia, and radix ophiopogonois and fructus schizandrae; radix ginseng, radix salvia miltiorrhiza and rhizoma corydalis was the most effective one among all the formulaes. These results were consistent with validation experiments.</p><p><b>CONCLUSION</b>Studying compatibility principle of TCMF by network theory is a new and feasible method.</p>